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Advanced Collaborative Emissions Study (ACES) Subchronic Exposure Results: Biologic Responses in Rats and Mice and Assessment of Genotoxicity
Report #: 166, Publication Type: Research Reports Author: McDonald, Jacob D et al. (Part 1); Jeffrey C Bemis et al. (Part 2); Lance M Hallberg et al. (Part 3); Daniel J Conklin and Maiying Kong (Part 4), 2012-09-25 Order this Publication About This Publication
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Part 1. Biologic Responses in Rats and Mice to Subchronic Inhalation of Diesel Exhaust from U.S. 2007-Compliant Engines: Report on 1-, 3-, and 12-Month Exposures in the ACES Bioassay.
McDonald JD, Doyle-Eisele M, Gigliotti A, Miller RA, Seilkop S, Mauderly JL, Seagrave J, Chow J, Zielinska B.
Part 2. Assessment of Genotoxicity After Exposure to Diesel Exhaust from U.S. 2007-Compliant Diesel Engines: Report on 1- and 3-Month Exposures in the ACES Bioassay.
Bemis, JC, Torous DK, Dertinger SD.
Part 3. Assessment of Genotoxicity and Oxidative Stress After Exposure to Diesel Exhaust from U.S. 2007-Compliant Diesel Engines: Report on 1- and 3-Month Exposures in the ACES Bioassay.
Hallberg LM, Ward JB, Hernandez C, Ameredes BT, Wickliffe JK.
Part 4. Effects of Subchronic Diesel Engine Emissions Exposure on Plasma Markers in Rodents: Report on 1- and 3-Month Exposures in the ACES Bioassay.
Conklin DJ and Kong M.
This report provides the first systematic look at the health effects of exposures to emissions from a new technology heavy-duty diesel engine. Included in this report are results obtained in rats and mice exposed for 1 and 3 months (and some results in rats at 12 months) to exhaust from a 2007-compliant diesel engine with aftertreatment to reduce particulate matter concentrations. Part 1 describes the core inhalation study by Drs. Jake McDonald and Joe Mauderly of the Lovelace Respiratory Research Institute, with results on general organ toxicity, lung histopathology, pulmonary function, and markers of inflammation and oxidative stress in blood and lung lavage fluid. Parts 2 and 3 describe studies by Drs. Jeffrey Bemis of Litron Laboratories and Lance Hallberg of the University of Texas Medical Branch, respectively, assessing genotoxic endpoints in the exposed rodents. Part 4 describes a study of vascular markers by Daniel Conklin of the University of Louisville. The Preface to this report contains background information about the planning and designing of the study, including decisions regarding the diesel exhaust dilutions and the choice of rodent strains.
The Appendices listed below are Available on the Web only (i.e. they are not part of the printed report).
Title Description Size 4/12/2012. 96 kb 9/25/2012. Parts 1–4. Includes a Statement and a Commentary by the HEI ACES Review Panel. This posting of Research Report 166 includes Part 4, Conklin et al. and its evaluation by the ACES Review Panel. No changes were made to Parts 1-3 or their respective evaluations by the ACES Review Panel since the initial posting of Parts 1-3 on 4/19/12. 6290 kb 9/25/2012. 115 kb 4/12/2012. Memorandum on Rat Strain Decision. 481 kb 4/12/2012. ACES Phase 3B Protocol. 350 kb 4/12/2012. ACES Three-Way ANOVA Results at 4 and 13 Weeks. 254 kb 9/25/2012. Summary and Evaluation of ACES Phase 3B Chamber Diesel Exhaust Generation and Characterization. 344 kb
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