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Reanalysis of the Harvard Six Cities Study and the American Cancer Society Study of Particulate Air Pollution and Mortality
Report #: Special Report, Publication Type: Special Reports
Author: Health Effects Institute,  2000-01-01 Order this Publication
About This Publication A Special Report of the Institute’s Particle Epidemiology Reanalysis Project.
The overall objective of this project was to conduct a rigorous and independent assessment of the findings of the Harvard Six Cities and American Cancer Society Studies of air pollution and mortality. This objective was met in two parts. In Part I: Replication and Validation, the Reanalysis Team led by Dr. Daniel Krewski sought to replicate the original studies via a quality assurance audit of a sample of the original data and to validate the original numeric results. In Part II: Sensitivity Analyses, they tested the robustness of the original analyses to alternate risk models and analytic approaches.

Table of Contents:
- HEI Statement
- Preface
- Contributors to the Project
- Investigators’
report: Reanalysis of the Harvard Six Cities Study and the American Cancer Society Study of Particulate Air Pollution and Mortality. Daniel Krewski, Richard T Burnett, Mark S Goldberg, Kristin Hoover, Jack Siemiatycki, Michael Jerrett, Michal Abrahamowicz, and Warren H White
- Health Review Committee\'s Commentary
- Original Investigators



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We recommend reading this for a full overview of the Reanalysis Project and its results. Includes the HEI Statement; Preface; Key portions of the Investigators' Report (Summary of Parts I and II, Introduction, Tables of Contents for Parts I and II); Commentary by the HEI Health Review Committee; Comments on the Reanalysis Project from the Original Investigators and the original articles that were the basis for the Reanalysis Project.2955 kb
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Includes Parts I and II with detailed analyses and results conducted by the Reanalysis Team, led by Daniel Krewski. 7431 kb
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For addition to the printed report. This page has been added to the electronic version of the report. 0 kb
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Computer Programs and Output Used in the Replication of the Original Analyses of the Harvard Six Cities Study. 4718 kb
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Computer Programs and Output Used in the Replication of the Original Analyses of the American Cancer Society Study. Pages 1-184.
Due to the size of the file, Part I Appendix F has been split into two files. Section 1 contains pages 1-184.
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Computer Programs and Output Used in the Replication of the Original Analyses of the American Cancer Society Study. Pages 185-359.
Due to the size of the file, Part I Appendix F has been split into two files. Section 2 contains pages 185-359.
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Quality Assurance Audit of the Data. 1156 kb
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Occupational Exposures.1886 kb
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Flexible Modeling of the Effects of Fine Particles and Sulfate on Mortality. 1180 kb
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Alternate Air Pollution Data in the ACS Study.355 kb
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Selection of Ecologic Covariates for the ACS Study.996 kb
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Definition of Metropolitan Areas in the ACS Study. 675 kb
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Values of the Ecologic Covariates. 911 kb
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Spatial Analyses. 1070 kb
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Random Effects Cox Models. 421 kb


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